Functional Connection between Deimination and Deacetylation of Histones

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Functional connection between deimination and deacetylation of histones.

Histone methylation plays key roles in regulating chromatin structure and function. The recent identification of enzymes that antagonize or remove histone methylation offers new opportunities to appreciate histone methylation plasticity in the regulation of epigenetic pathways. Peptidylarginine deiminase 4 (PADI4; also known as PAD4) was the first enzyme shown to antagonize histone methylation....

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 2009

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.00285-09